Irby may refer to:
- Irby (surname), a list of people
- Irby, Merseyside, England, a village
- Irby, Virginia, United States, an unincorporated community
- Irby, Washington, United States, an unincorporated community
- Irby in the Marsh, Lincolnshire, England
- Irby upon Humber, Lincolnshire, England