Irene Cheng, née Hotung, also known as Tsi-dsi Irene Ho (October 21, 1904 – February 17, 2007; Chinese: 鄭何艾齡), was a Hong Kong educationalist. The first Chinese woman to graduate from the University of Hong Kong, she went on to become the highest-ranking woman in the city's Education Department. Throughout her career, she also worked as an educator in mainland China and in the United States.