Irene Komnene Laskarina Branaina (Greek: Ειρήνη Κομνηνή Λασκαρίνα Βρανᾶίνα; died around 1271) was a Byzantine noblewoman and wife of sebastokrator Constantine Palaiologos, half-brother of Byzantine Emperor Michael VIII Palaiologos. She seems to have followed suit after her husband's retirement to a convent, and taken the monastic name of Maria. She probably died as a nun.