| Irene Palaiologina | |
|---|---|
| Empress consort of the Byzantine Empire | |
| Tenure | 15 April 1353-1357 |
| Died | after 1356 |
| Spouse | Matthew Kantakouzenos |
| Issue | John Kantakouzenos Demetrios I Kantakouzenos Theodora Kantakouzene Helena Kantakouzene Maria Kantakouzene Theodore Kantakouzenos (?) |
| House | Palaiologos |
| Father | Demetrios Palaiologos |
| Mother | Theodora Komnene |
Irene Palaiologina (died after 1356) was the empress consort of Matthew Kantakouzenos.