| Irene Palaiologina | |
|---|---|
| Empress and Autocrat of all the East and Perateia | |
| Empress regnant of Trebizond | |
| Reign | 6 April 1340 – 17 July 1341 |
| Predecessor | Basil |
| Successor | Anna |
| Empress consort of Trebizond | |
| Tenure | 1335–1339 |
| Born | c. 1315 |
| Spouse | Basil Megas Komnenos |
| Dynasty | Palaiologos |
| Father | Andronikos III Palaiologos |
Irene Palaiologina (Greek: Ειρήνη Παλαιολογίνα, Eirēnē Palaiologina), (c. 1315 – after 1341) was Empress regnant of Trebizond from April 6, 1340, to July 17, 1341. She was an illegitimate daughter of the Byzantine Emperor Andronikos III Palaiologos, and she married Emperor Basil of Trebizond in 1335.