Iron-binding proteins

Iron-binding proteins are carrier proteins and metalloproteins that are important in iron metabolism[1] and the immune response.[2][3] Iron is required for life.

Iron-dependent enzymes catalyze a variety of biochemical reactions and can be divided into three broad classes depending on the structure of their active site: non-heme mono-iron, non-heme diiron , or heme centers.[4] A well-known family of iron-dependent enzymes include oxygenases that facilitate hydroxyl group addition of one or both atoms from o2. Notable enzymes include tryptophan dioxygenase, ferredoxin, and 2-oxoglutarate dioxygenase.[5]

  1. ^ Brock JH (1989). "Iron-binding proteins". Acta Paediatrica Scandinavica. Supplement. 361: 31–43. doi:10.1111/apa.1989.78.s361.31. PMID 2485582. S2CID 44752615.
  2. ^ De Sousa M, Breedvelt F, Dynesius-Trentham R, Trentham D, Lum J (1988). "Iron, iron-binding proteins and immune system cells". Annals of the New York Academy of Sciences. 526 (1): 310–22. Bibcode:1988NYASA.526..310S. doi:10.1111/j.1749-6632.1988.tb55515.x. PMID 3291685. S2CID 12756539.
  3. ^ Kaplan J, Ward DM (August 2013). "The essential nature of iron usage and regulation". Current Biology. 23 (15): R642-6. doi:10.1016/j.cub.2013.05.033. PMC 3928970. PMID 23928078.
  4. ^ Solomon EI, Brunold TC, Davis MI, Kemsley JN, Lee SK, Lehnert N, Neese F, Skulan AJ, Yang YS, Zhou J (January 2000). "Geometric and electronic structure/function correlations in non-heme iron enzymes". Chemical Reviews. 100 (1): 235–350. doi:10.1021/cr9900275. PMID 11749238.
  5. ^ Cheng AX, Han XJ, Wu YF, Lou HX (January 2014). "The function and catalysis of 2-oxoglutarate-dependent oxygenases involved in plant flavonoid biosynthesis". International Journal of Molecular Sciences. 15 (1): 1080–95. doi:10.3390/ijms15011080. PMC 3907857. PMID 24434621.