Irwin Rose

Irwin Rose
Irwin Rose, c. 2000
Born
Irwin Allan Rose

(1926-07-16)July 16, 1926
DiedJune 2, 2015(2015-06-02) (aged 88)
Alma materUniversity of Chicago (BS, PhD) NYU (postdoc)
Known forUbiquitin-mediated protein degradation
SpouseZelda Budenstein[1]
Children4[1]
AwardsNobel Prize in Chemistry (2004)
Scientific career
FieldsBiology
Institutions
ThesisStudies on the Biochemical Synthesis of Nucleic Acids (1952)
Doctoral advisorBernard S. Schweigert

Irwin Allan Rose (July 16, 1926 – June 2, 2015) was an American biologist. Along with Aaron Ciechanover and Avram Hershko, he was awarded the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation.[2][1][3]

  1. ^ a b c Rose, I (11 August 2005). "Early work on the ubiquitin proteasome system, an interview with Irwin Rose". Cell Death & Differentiation. 12 (9). Springer Science and Business Media LLC: 1162–1166. doi:10.1038/sj.cdd.4401700. ISSN 1350-9047. PMID 16094392.
  2. ^ Wilkinson, Keith; Hershko, Avram (2015). "Irwin Allan Rose (1926–2015) Established role of ubiquitin in the destruction of cellular proteins". Nature. 523 (7562): 532. doi:10.1038/523532a. ISSN 0028-0836. PMID 26223618.
  3. ^ Hershko, A.; Ciechanover, A.; Rose, I.A. (1979), "Resolution of the ATP-dependent proteolytic system from reticulocytes: a component that interacts with ATP", Proc. Natl. Acad. Sci. USA, 76 (7): 3107–3110, Bibcode:1979PNAS...76.3107H, doi:10.1073/pnas.76.7.3107, PMC 383772, PMID 290989.