Isaac Anderson may refer to:
- Isaac Anderson (congressman) (1760–1838), member of the U.S. House of Representatives from Pennsylvania, officer in the American Revolution
- Isaac Anderson (1868–1961), New York journalist and mystery critic for The New York Times Book Review
- Isaac H. Anderson (1834–1906), slave who became a wealthy businessman, politician and religious leader in the U.S. state of Georgia
- Isaac L. Anderson (1780–1857), Presbyterian minister and founder of Maryville College
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