Isaac Edward Holmes | |
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| Member of the U.S. House of Representatives from South Carolina | |
| In office March 4, 1839 – March 3, 1851 | |
| Preceded by | Hugh S. Legaré |
| Succeeded by | William Aiken Jr. |
| Constituency | 1st district (1839–43) 6th district (1843–51) |
| Member of the South Carolina House of Representatives from St. Philip's and St. Michael's Parish | |
| In office November 27, 1826 – December 18, 1829 | |
| In office November 26, 1832 – December 29, 1833 | |
| Personal details | |
| Born | April 6, 1796 Charleston, South Carolina |
| Died | February 24, 1867 (aged 70) Charleston, South Carolina |
| Political party | Democratic |
| Alma mater | Yale College |
| Profession | lawyer, politician |
| Signature | .png){kind=small} |
Isaac Edward Holmes (April 6, 1796 – February 24, 1867) was a U.S. Representative from South Carolina.