Isabella of Spain

Isabella of Spain or Isabel of Spain may refer to:

• Isabella I of Castile (1451–1504), queen
• Isabella II of Spain (1830–1904), queen
• Isabella of Austria (1501–1526)
• Infanta Isabella Clara Eugenia of Spain (1566–1633), archduchess of the Netherlands
• María Isabella of Spain (1789–1848)
• Isabella, Princess of Asturias (1851–1931)