Isamu Yokoyama | |
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| Native name | 横山勇 |
| Born | 1 March 1889 Chiba Prefecture, Empire of Japan |
| Died | 21 April 1952 (aged 63) Sugamo Prison, Tokyo, Occupied Japan |
| Allegiance |  Empire of Japan |
| Service |  Imperial Japanese Army |
| Years of service | 1909–1945 |
| Rank |  Lieutenant General |
| Battles / wars | Second Sino-Japanese War World War II |
Isamu Yokoyama (横山勇, Yokoyama Isamu, 1 March 1889 – 21 April 1952) was a general in the Imperial Japanese Army, commanding Japanese ground forces in China during the Second Sino-Japanese War and Pacific War. In 1948, he was sentenced to death by a military commission for Yokohama War Crimes Trials due to his direct command responsibility for vivisection and other human medical experiments performed at the Kyushu Imperial University on downed Allied airmen.