Isradipine

Isradipine

Clinical data
Trade names	DynaCirc
AHFS/Drugs.com	Monograph
MedlinePlus	a693048
Pregnancy category	C
Routes of administration	Oral
ATC code	C08CA03 (WHO)
Legal status
Legal status	UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability	15-24%
Protein binding	95%
Metabolism	100% Hepatic
Elimination half-life	8 hours
Excretion	70% Renal, 30% Fecal
Identifiers
IUPAC name 3-Methyl 5-propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
CAS Number	75695-93-1 Y
PubChem CID	3784
DrugBank	DB00270 Y
ChemSpider	3652 Y
UNII	YO1UK1S598
KEGG	D00349 Y
ChEMBL	ChEMBL1648 Y
CompTox Dashboard (EPA)	DTXSID4023179
ECHA InfoCard	100.158.721
Chemical and physical data
Formula	C19H21N3O5
Molar mass	371.393 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(OC)\C3=C(\N\C(=C(\C(=O)OC(C)C)C3c1cccc2nonc12)C)C
InChI InChI=1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3 Y Key:HMJIYCCIJYRONP-UHFFFAOYSA-N Y
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Isradipine (tradenames DynaCirc, Prescal) is a calcium channel blocker of the dihydropyridine class. It is usually prescribed for the treatment of high blood pressure in order to reduce the risk of stroke and heart attack.

It was patented in 1978 and approved for medical use in 1989.^[1]