Ixabepilone

Ixabepilone
Clinical data
Trade namesIxempra
Other namesAzaepothilone B
AHFS/Drugs.comMonograph
MedlinePlusa608042
License data
Routes of
administration		Intravenous infusion
ATC code
Legal status
Legal status
Pharmacokinetic data
BioavailabilityN/A
Protein binding67 to 77%
MetabolismExtensive, hepatic, CYP3A4-mediated
Elimination half-life52 hours
ExcretionFecal (mostly) and renal
Identifiers
  • (1R,5S,6S,7R,10S,14S,16S)-6,10-dihydroxy-1,5,7,
    9,9-pentamethyl-14-[(E)-1-(2-methyl-1,3-thiazol-
    4-yl)prop-1-en-2-yl]-17-oxa-13-azabicyclo[14.1.0]
    heptadecane-8,12-dione
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.158.736 Edit this at Wikidata
Chemical and physical data
FormulaC27H42N2O5S
Molar mass506.70 g·mol−1
3D model (JSmol)
  • Cc3nc(/C=C(\C)[C@@H]1C[C@@H]2O[C@]2(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)N1)cs3
  • InChI=1S/C27H42N2O5S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)29-23(31)13-21(30)26(5,6)25(33)17(3)24(15)32/h11,14-15,17,20-22,24,30,32H,8-10,12-13H2,1-7H3,(H,29,31)/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1 checkY
  • Key:FABUFPQFXZVHFB-PVYNADRNSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Ixabepilone (INN; also known as azaepothilone B, codenamed BMS-247550) is a pharmaceutical drug developed by Bristol-Myers Squibb as a chemotherapeutic medication for cancer.[2]

  1. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
  2. ^ "More information on cancer drugs". www.cancer.org.