Jacques Lisfranc de St. Martin (12 April 1787 in Saint-Paul-en-Jarez – 13 May 1847) was a pioneering French surgeon and gynecologist. He pioneered a number of operations including removal of the rectum, lithotomy in women, and amputation of the cervix uteri.
He studied medicine in Lyon and Paris, where he worked as an assistant to Guillaume Dupuytren. In 1826 he became director of his own department at the Hôpital de la Pitié, from where he gave classes in clinical medicine. The Lisfranc joint and the Lisfranc fracture are named after him.
Jacques Lisfranc is buried in the Cimetière du Montparnasse in Paris.