James O'Donnell may refer to:
- James O'Donnell (architect) (1774–1830), architect
- James O'Donnell (organist) (born 1961), organist of Westminster Abbey
- James O'Donnell (politician) (1840–1915), United States Representative from Michigan
- James O'Donnell (rugby union) (1860–1942), New Zealand rugby player
- Jimmy O'Donnell (James M. O'Donnell, 1872–1946), American sports promoter and founder of the NFL's Cleveland Tigers
- James J. O'Donnell, former provost of Georgetown University
- James P. O'Donnell (1917–1990), historian
- James P. O'Donnell (politician) (1920–1997), Pennsylvania politician
This disambiguation page lists articles about people with the same name.
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