Janis is a given name. Notable people with the name include:
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- Janis Amatuzio (born 1950), American forensic pathologist
- Janis Antonovics (born 1942), Latvian-British-American biologist
- Janis Babson (1950–1961), Canadian child, organ donation
- Janis Carter (1913–1994), American actress
- Jānis Daliņš (1904–1978), Latvian athlete
- Janis Hughes (born 1958), British politician
- Janis Ian (born 1951), American songwriter and folksinger
- Janis Irwin (born 1984), Canadian politician
- Janis Johnson (born 1946), Canadian politician
- Janis Joplin (1943–1970), American singer and songwriter
- Janis Kelly (volleyball) (born 1971), Canadian volleyball player
- Janis Kelly (soprano), Scottish opera singer
- Janis Paige (1922–2024), American actress
- Janis Rozentāls (1866–1916), Latvian painter
- Janis Tanaka (born 1963), American bassist
- Janis Winehouse, British pharmacist, mother of Amy Winehouse