Janus kinase 3

JAK3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4RIO, 1YVJ, 3LXK, 3LXL, 3PJC, 3ZC6, 3ZEP, 4HVD, 4HVG, 4HVH, 4HVI, 4I6Q, 4QPS, 4QT1, 4V0G, 4Z16
Identifiers
Aliases	JAK3, JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK, Janus kinase 3
External IDs	OMIM: 600173; MGI: 99928; HomoloGene: 181; GeneCards: JAK3; OMA:JAK3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	17,848,071 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	72,143,219 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; spleen; ; lymph node; ; monocyte; ; appendix; ; mucosa of ileum; ; left ovary; ; right ovary; ; epithelium of nasopharynx;
	Top expressed in
	lactiferous gland; ; granulocyte; ; thymus; ; muscle of thigh; ; lymph node; ; yolk sac; ; right kidney; ; spleen; ; subcutaneous adipose tissue; ; mesenteric lymph nodes;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; non-membrane spanning protein tyrosine kinase activity; kinase activity; protein binding; protein tyrosine kinase activity; protein phosphatase binding; signaling receptor binding; ATP binding;
Cellular component	cytoplasm; membrane; extrinsic component of cytoplasmic side of plasma membrane; cytoskeleton; endomembrane system; cytosol; endosome; plasma membrane;
Biological process	negative regulation of FasL production; negative regulation of interleukin-10 production; growth hormone receptor signaling pathway via JAK-STAT; response to interleukin-15; intracellular signal transduction; adaptive immune response; response to interleukin-4; phosphorylation; interleukin-4-mediated signaling pathway; immune system process; response to interleukin-2; negative regulation of thymocyte apoptotic process; MAPK cascade; T cell homeostasis; tyrosine phosphorylation of STAT protein; protein phosphorylation; negative regulation of T-helper 1 cell differentiation; negative regulation of dendritic cell cytokine production; regulation of T cell apoptotic process; positive regulation of T cell proliferation; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; B cell differentiation; negative regulation of T cell activation; enzyme linked receptor protein signaling pathway; cell migration; response to interleukin-9; negative regulation of interleukin-12 production; innate immune response; inflammatory response; erythrocyte differentiation; regulation of apoptotic process; interleukin-7-mediated signaling pathway; interleukin-15-mediated signaling pathway; interleukin-9-mediated signaling pathway; cytokine-mediated signaling pathway; interleukin-2-mediated signaling pathway; interleukin-21-mediated signaling pathway; regulation of receptor signaling pathway via JAK-STAT;
	Sources:Amigo / QuickGO
Orthologs
	3718
	16453
	ENSG00000105639
	ENSMUSG00000031805
	P52333
	Q62137
	NM_000215
	NM_001190830; NM_010589
	NP_000206
	NP_001177759; NP_034719
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosine-protein kinase JAK3 is a tyrosine kinase enzyme that in humans is encoded by the JAK3 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105639 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031805 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Riedy MC, Dutra AS, Blake TB, Modi W, Lal BK, Davis J, Bosse A, O'Shea JJ, Johnston JA (October 1996). "Genomic sequence, organization, and chromosomal localization of human JAK3". Genomics. 37 (1): 57–61. doi:10.1006/geno.1996.0520. PMID 8921370.
^ Hoffman SM, Lai KS, Tomfohrde J, Bowcock A, Gordon LA, Mohrenweiser HW (July 1997). "JAK3 maps to human chromosome 19p12 within a cluster of proto-oncogenes and transcription factors". Genomics. 43 (1): 109–11. doi:10.1006/geno.1997.4792. PMID 9226382.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105639 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031805 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8921370-5] Riedy MC, Dutra AS, Blake TB, Modi W, Lal BK, Davis J, Bosse A, O'Shea JJ, Johnston JA (October 1996). "Genomic sequence, organization, and chromosomal localization of human JAK3". Genomics. 37 (1): 57–61. doi:10.1006/geno.1996.0520. PMID 8921370.

[pmid9226382-6] Hoffman SM, Lai KS, Tomfohrde J, Bowcock A, Gordon LA, Mohrenweiser HW (July 1997). "JAK3 maps to human chromosome 19p12 within a cluster of proto-oncogenes and transcription factors". Genomics. 43 (1): 109–11. doi:10.1006/geno.1997.4792. PMID 9226382.

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