Jean-Louis is a given name, especially for French males.
Notable people named "Jean-Louis" include:
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- Jean-Louis Alléon-Dulac, French naturalist
- Jean-Louis Aubert, French singer-songwriter, guitarist, composer and producer
- Jean-Louis Baribeau, Canadian politician and a Member of the House of Commons
- Jean-Louis Barrault, French actor, director and mime artist
- Jean-Louis Baudelocque, French obstetrician
- Jean-Louis Beaudry, Canadian politician and entrepreneur
- Jean-Louis Beffa, French businessman
- Jean-Louis Béland, Canadian politician and Member of the National Assembly of Quebec
- Jean-Louis Bergheaud, better known as Jean-Louis Murat
- Jean-Louis Berlandier, French-Mexican naturalist, physician, and anthropologist
- Jean Louis Berthauldt (1907–1997), a French-born costume designer also known as Jean Louis
- Jean-Louis Borloo, French politician
- Jean-Louis Bourlanges, French politician
- Jean-Louis Bruguière, French judge
- Jean-Louis Buffet, French musical instrument maker
- Jean-Louis Carra (fr) (1742–1793), a French activist and politician
- Jean-Louis Gassée (born 1944), best known as an executive at Apple Computer (1981–1990), later founder of Be Inc
- Jean-Louis Koszul, French mathematician
- Jean-Louis Lefebvre de Cheverus, a French-born American cardinal
- Jean-Louis Loday, French mathematician
- Jean-Louis Mandengue (born 1971), a French boxer
- Jean-Louis Masurel, a French businessman
- Jean-Louis Michel (fencer), Dominican Creole master in the art of fencing
- Jean-Louis Murat, French singer
- Jean-Louis Palladin, French chef of eponymous restaurant in Washington, DC
- Jean-Louis Schneiter, French politician
- Jean-Louis Thiériot (born 1969), French politician
- Jean-Louis Valois French professional footballer
- Jean-Louis Vieillard-Baron (born 1944), French philosopher