Jean Astruc (19 March 1684, in Sauve, France – 5 May 1766, in Paris) was a professor of medicine in France at Montpellier and Paris, who wrote the first great treatise on syphilis and venereal diseases, and also, with a small anonymously published book, played a fundamental part in the origins of critical textual analysis of works of the Bible. Astruc was the first to propose and hypothesize, by using the techniques of textual analysis that were commonplace in studying the secular classics, the theory that Genesis was composed based on several sources or manuscript traditions, an approach now called the documentary hypothesis.