Joe Cain (disambiguation)

Joe Cain (1832–1904) was a Native American.

Joe or Joseph Cain may also refer to:

• Joe Cain (American football) (born 1965), American football linebacker
• Joe Cain (historian of science) (born 1964)
• Joe Cain (rugby union) for Leicester Tigers
• Joseph Alexander Cain (1920–1980), American painter, art educator and critic
• Joseph Hilliard Cain Sr. (1892–1962), American military officer and politician