Joe Z. Tsien（钱卓）[1] is a neuroscientist who pioneered Cre/lox-neurogenetics in the mid-1990s,[2] a versatile toolbox for neuroscientists to study the complex relationships between genes, neural circuits, and behaviors.[3] He is also known as the creator of the smart mouse Doogie in the late 1990s while being a faculty member at Princeton University.[4][5]
Recently, he developed the Theory of Connectivity in an effort to explain the origin of intelligence, or the basic design principle underlying brain computation and intelligence.[6][7] The theory states that brain computation is organized by a power-of-two-based permutation logic in constructing cell assemblies - the basic building blocks of neural circuits.[8] The theory has received a set of validation from multiple experiments. The discovery of this basic computational logic of the brain can have important implications for the development of artificial general intelligence.
In addition, Tsien has also postulated the Neural Self-Information Theory to describe how the brain encodes the moment-to-moment perceptions, memories, spatial navigation, decision-making and conscious action executions. [9] [10] The Neural Self-Information Theory and Theory of Connectivity may provide two fundamental frameworks to not only understand how the brain works, but also the development of brain-inspired neuromorphic computation.
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