John C. Vaughn | |
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| Born | February 24, 1824 Monroe County, Tennessee, U.S. |
| Died | September 10, 1875 (aged 51) |
| Place of burial | Greenwood, Georgia, U.S. |
| Allegiance | United States Confederate States |
| Service | United States Volunteers Confederate States Army |
| Years of service | 1847-1848 1861-1865 |
| Rank | Captain Brigadier-General |
| Battles / wars | Mexican–American War American Civil War |
John Crawford Vaughn (February 24, 1824 – September 10, 1875) was a Confederate cavalry officer from East Tennessee. He served in the Mexican–American War, prospected in the California Gold Rush, and participated in American Civil War battles including First Manassas, Vicksburg, Piedmont and Saltville.