John Erskine, 5th Lord Erskine (7 July 1487 – 11 November 1555) was a Scottish nobleman.
He was the son of Robert Erskine, 4th Lord Erskine (died 1513) and Isabel Campbell, a daughter of George Campbell of Loudon.
His family was claimant to the earldom of Mar; this was recognized in 1565 for his son, John. Following a dynastic dispute in the 19th century, John Lord Erskine was acknowledged, retrospectively, as the 17th Earl.