John Hoffman may refer to:
- John Hoffman (filmmaker) (1904–1980), American montage editor and filmmaker
- John Hoffman (defensive end) (born 1943), American football defensive end
- John Hoffman (running back) (1925–1987), American football running back
- John Hoffman (baseball) (1943–2001), Major League Baseball catcher
- John Jay Hoffman (born 1965), acting attorney general of New Jersey
- John Robert Hoffman, American actor/screenwriter
- John T. Hoffman (1828–1888), Governor of New York, 1869–1872
- John Hoffman (Minnesota politician) (born 1965), Minnesota state senator
- John Hoffman (Illinois politician), sheriff of Cook County
- John D. Hoffman (1904–2004), American chemist and author
- John H. Hoffman, space scientist