Joseph Locke (1805–1860) was a British civil engineer particularly associated with railway projects.
Joseph Locke may also refer to:
- Joe Locke (actor) (born 2003; Joseph William Locke), a Manx actor
- Joe Locke (musician) (born 1959; Joseph Paul Locke), an American jazz vibraphonist and composer
- Josef Locke (1917–1999; born Joseph McLaughlin), an Irish popular singer of the 1940s and 1950s
- Joseph Locke, penname of Ray Garton (1962–2024), an American author