KCNA2

KCNA2
Identifiers
Aliases	KCNA2, HBK5, HK4, HUKIV, KV1.2, MK2, NGK1, RBK2, EIEE32, potassium voltage-gated channel subfamily A member 2, DEE32
External IDs	OMIM: 176262; MGI: 96659; HomoloGene: 21034; GeneCards: KCNA2; OMA:KCNA2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	110,631,474 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	107,022,321 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; middle temporal gyrus; ; lateral nuclear group of thalamus; ; postcentral gyrus; ; primary visual cortex; ; cerebellar vermis; ; superior frontal gyrus; ; pons; ; Brodmann area 46; ; endothelial cell;
	Top expressed in
	lateral geniculate nucleus; ; pontine nuclei; ; lobe of cerebellum; ; medial geniculate nucleus; ; anterior horn of spinal cord; ; medial vestibular nucleus; ; medial dorsal nucleus; ; deep cerebellar nuclei; ; cerebellar vermis; ; facial motor nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	potassium channel activity; voltage-gated ion channel activity; ion channel activity; protein binding; voltage-gated potassium channel activity; delayed rectifier potassium channel activity; outward rectifier potassium channel activity; kinesin binding;
Cellular component	juxtaparanode region of axon; axon terminus; integral component of membrane; perikaryon; cell projection; endoplasmic reticulum membrane; membrane; voltage-gated potassium channel complex; plasma membrane; synapse; integral component of plasma membrane; neuronal cell body membrane; axon; cell junction; dendrite; endoplasmic reticulum; neuron projection; lamellipodium membrane; presynaptic membrane; lamellipodium; potassium channel complex; paranodal junction; calyx of Held; integral component of presynaptic membrane;
Biological process	regulation of dopamine secretion; regulation of ion transmembrane transport; ion transport; optic nerve structural organization; potassium ion transport; transmembrane transport; potassium ion transmembrane transport; regulation of circadian sleep/wake cycle, non-REM sleep; protein homooligomerization; protein complex oligomerization; sensory perception of pain; neuronal action potential;
	Sources:Amigo / QuickGO
Orthologs
	3737
	16490
	ENSG00000177301
	ENSMUSG00000040724
	P16389
	P63141
	NM_001204269; NM_004974
	NM_008417
	NP_001191198; NP_004965
	NP_032443
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium voltage-gated channel subfamily A member 2 also known as K_v1.2 is a protein that in humans is encoded by the KCNA2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000177301 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040724 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X (December 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacological Reviews. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
^ "Entrez Gene: KCNA2 potassium voltage-gated channel, shaker-related subfamily, member 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000177301 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040724 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16382104-5] Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X (December 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacological Reviews. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

[entrez-6] "Entrez Gene: KCNA2 potassium voltage-gated channel, shaker-related subfamily, member 2".

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