KCNE3

KCNE3
Identifiers
Aliases	KCNE3, HOKPP, HYPP, MiRP2, potassium voltage-gated channel subfamily E regulatory subunit 3, BRGDA6
External IDs	OMIM: 604433; MGI: 1891124; HomoloGene: 3994; GeneCards: KCNE3; OMA:KCNE3 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	74,467,729 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	99,834,076 bp
RNA expression pattern
	Top expressed in
	nasal epithelium; ; monocyte; ; mucosa of ileum; ; duodenum; ; bronchial epithelial cell; ; mucosa of sigmoid colon; ; pancreatic ductal cell; ; pylorus; ; rectum; ; blood;
	Top expressed in
	spermatid; ; left colon; ; crypt of lieberkuhn of small intestine; ; spermatocyte; ; seminiferous tubule; ; duodenum; ; Paneth cell; ; migratory enteric neural crest cell; ; jejunum; ; ileum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	potassium channel activity; transmembrane transporter binding; voltage-gated ion channel activity; potassium channel regulator activity; protein binding; voltage-gated potassium channel activity; delayed rectifier potassium channel activity; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization;
Cellular component	cytoplasm; integral component of membrane; vesicle; perikaryon; cell projection; membrane; voltage-gated potassium channel complex; plasma membrane; neuronal cell body membrane; dendrite; membrane raft;
Biological process	regulation of potassium ion transport; positive regulation of voltage-gated calcium channel activity; regulation of ion transmembrane transport; ion transport; potassium ion transport; potassium ion transmembrane transport; negative regulation of delayed rectifier potassium channel activity; regulation of heart rate by cardiac conduction; negative regulation of potassium ion export across plasma membrane; negative regulation of voltage-gated potassium channel activity; negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential; regulation of ventricular cardiac muscle cell membrane repolarization; ventricular cardiac muscle cell action potential; membrane repolarization during action potential; membrane repolarization during ventricular cardiac muscle cell action potential; potassium ion export across plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	10008
	57442
	ENSG00000175538
	ENSMUSG00000035165
	Q9Y6H6
	Q9WTW2
	NM_005472
NM_001190869; NM_001190870; NM_001190871; NM_001190950; NM_020574;
	NM_001360466; NM_001360467
	NP_005463
NP_001177798; NP_001177799; NP_001177800; NP_001177879; NP_065599;
	NP_001347395; NP_001347396
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium voltage-gated channel, Isk-related family, member 3 (KCNE3), also known as MinK-related peptide 2 (MiRP2) is a protein that in humans is encoded by the KCNE3 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000175538 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035165 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: KCNE3 potassium voltage-gated channel, Isk-related family, member 3".
^ Abbott GW, Sesti F, Splawski I, Buck ME, Lehmann MH, Timothy KW, Keating MT, Goldstein SA (Apr 1999). "MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia". Cell. 97 (2): 175–87. doi:10.1016/S0092-8674(00)80728-X. PMID 10219239. S2CID 8507168.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000175538 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035165 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: KCNE3 potassium voltage-gated channel, Isk-related family, member 3".

[pmid10219239-6] Abbott GW, Sesti F, Splawski I, Buck ME, Lehmann MH, Timothy KW, Keating MT, Goldstein SA (Apr 1999). "MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia". Cell. 97 (2): 175–87. doi:10.1016/S0092-8674(00)80728-X. PMID 10219239. S2CID 8507168.

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