KCNE4

KCNE4
Identifiers
Aliases	KCNE4, MIRP3, potassium voltage-gated channel subfamily E regulatory subunit 4
External IDs	OMIM: 607775; MGI: 1891125; HomoloGene: 10959; GeneCards: KCNE4; OMA:KCNE4 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	223,198,399 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	78,797,745 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; gallbladder; ; tibial arteries; ; pericardium; ; smooth muscle tissue; ; Achilles tendon; ; myometrium; ; islet of Langerhans; ; testicle; ; ascending aorta;
	Top expressed in
	ascending aorta; ; aortic valve; ; calvaria; ; efferent ductule; ; dermis; ; tunica media of zone of aorta; ; condyle; ; carotid body; ; uterus; ; vas deferens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; voltage-gated ion channel activity; transmembrane transporter binding; voltage-gated potassium channel activity; potassium channel activity; delayed rectifier potassium channel activity; potassium channel regulator activity; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization;
Cellular component	apical plasma membrane; membrane; integral component of membrane; voltage-gated potassium channel complex;
Biological process	ion transport; potassium ion transmembrane transport; potassium ion transport; regulation of ion transmembrane transport; regulation of ventricular cardiac muscle cell membrane repolarization; ventricular cardiac muscle cell action potential; membrane repolarization during action potential; regulation of heart rate by cardiac conduction; membrane repolarization during ventricular cardiac muscle cell action potential; negative regulation of delayed rectifier potassium channel activity; potassium ion export across plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	23704
	57814
	ENSG00000152049
	ENSMUSG00000047330
	Q8WWG9
	Q9WTW3
	NM_080671
	NM_021342
	NP_542402
	NP_067317
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium voltage-gated channel subfamily E member 4, originally named MinK-related peptide 3 or MiRP3 when it was discovered, is a protein that in humans is encoded by the KCNE4 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000152049 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000047330 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Abbott GW, Sesti F, Splawski I, Buck ME, Lehmann MH, Timothy KW, Keating MT, Goldstein SA (April 1999). "MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia". Cell. 97 (2): 175–87. doi:10.1016/S0092-8674(00)80728-X. PMID 10219239. S2CID 8507168.
^ "Entrez Gene: KCNE4 potassium voltage-gated channel, Isk-related family, member 4".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000152049 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000047330 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10219239-5] Abbott GW, Sesti F, Splawski I, Buck ME, Lehmann MH, Timothy KW, Keating MT, Goldstein SA (April 1999). "MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia". Cell. 97 (2): 175–87. doi:10.1016/S0092-8674(00)80728-X. PMID 10219239. S2CID 8507168.

[entrez-6] "Entrez Gene: KCNE4 potassium voltage-gated channel, Isk-related family, member 4".

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