KCNIP4

KCNIP4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3DD4
Identifiers
Aliases	KCNIP4, CALP, KCHIP4, potassium voltage-gated channel interacting protein 4
External IDs	OMIM: 608182; MGI: 1933131; HomoloGene: 23528; GeneCards: KCNIP4; OMA:KCNIP4 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	21,948,772 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	49,524,907 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; middle temporal gyrus; ; pons; ; cerebellar vermis; ; Brodmann area 23; ; superior frontal gyrus; ; parietal lobe; ; superior vestibular nucleus; ; postcentral gyrus; ; ventral tegmental area;
	Top expressed in
	medial dorsal nucleus; ; lobe of cerebellum; ; medial geniculate nucleus; ; cerebellar vermis; ; medial vestibular nucleus; ; lateral geniculate nucleus; ; ventral tegmental area; ; supraoptic nucleus; ; mammillary body; ; superior colliculus;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; potassium channel regulator activity; potassium channel activity; voltage-gated ion channel activity; metal ion binding; protein binding;
Cellular component	cytoplasm; cytosol; voltage-gated potassium channel complex; plasma membrane; endoplasmic reticulum; membrane;
Biological process	potassium ion transport; regulation of ion transmembrane transport; protein localization to plasma membrane; ion transport; regulation of potassium ion transmembrane transport; potassium ion transmembrane transport; cardiac conduction;
	Sources:Amigo / QuickGO
Orthologs
	80333
	80334
	ENSG00000185774; ENSG00000281758
	ENSMUSG00000029088
	Q6PIL6
	Q6PHZ8
NM_001035003; NM_001035004; NM_025221; NM_147181; NM_147182;
	NM_147183; NM_001363504
	NM_001199242; NM_001199243; NM_001199244; NM_001199245; NM_030265
NP_001030175; NP_001030176; NP_079497; NP_671710; NP_671711;
	NP_671712; NP_001350433
	NP_001186171; NP_001186172; NP_001186173; NP_001186174; NP_084541
	Wikidata
View/Edit Human	View/Edit Mouse

Kv channel-interacting protein 4 is a protein that in humans is encoded by the KCNIP4 gene.^[5]^[6]^[7]

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily.^[8] Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.^[7]

^ ^a ^b ^c ENSG00000281758 GRCh38: Ensembl release 89: ENSG00000185774, ENSG00000281758 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029088 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Holmqvist MH, Cao J, Hernandez-Pineda R, Jacobson MD, Carroll KI, Sung MA, Betty M, Ge P, Gilbride KJ, Brown ME, Jurman ME, Lawson D, Silos-Santiago I, Xie Y, Covarrubias M, Rhodes KJ, Distefano PS, An WF (Jan 2002). "Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain". Proc Natl Acad Sci U S A. 99 (2): 1035–40. Bibcode:2002PNAS...99.1035H. doi:10.1073/pnas.022509299. PMC 117799. PMID 11805342.
^ Morohashi Y, Hatano N, Ohya S, Takikawa R, Watabiki T, Takasugi N, Imaizumi Y, Tomita T, Iwatsubo T (Apr 2002). "Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4". J Biol Chem. 277 (17): 14965–75. doi:10.1074/jbc.M200897200. PMID 11847232.
^ ^a ^b "Entrez Gene: KCNIP4 Kv channel interacting protein 4".
^ Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.

[refGRCh38Ensembl-1] ENSG00000281758 GRCh38: Ensembl release 89: ENSG00000185774, ENSG00000281758 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029088 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11805342-5] Holmqvist MH, Cao J, Hernandez-Pineda R, Jacobson MD, Carroll KI, Sung MA, Betty M, Ge P, Gilbride KJ, Brown ME, Jurman ME, Lawson D, Silos-Santiago I, Xie Y, Covarrubias M, Rhodes KJ, Distefano PS, An WF (Jan 2002). "Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain". Proc Natl Acad Sci U S A. 99 (2): 1035–40. Bibcode:2002PNAS...99.1035H. doi:10.1073/pnas.022509299. PMC 117799. PMID 11805342.

[pmid11847232-6] Morohashi Y, Hatano N, Ohya S, Takikawa R, Watabiki T, Takasugi N, Imaizumi Y, Tomita T, Iwatsubo T (Apr 2002). "Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4". J Biol Chem. 277 (17): 14965–75. doi:10.1074/jbc.M200897200. PMID 11847232.

[entrez-7] "Entrez Gene: KCNIP4 Kv channel interacting protein 4".

[pmid17311005-8] Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]