KCNJ5

KCNJ5
Identifiers
Aliases	KCNJ5, CIR, GIRK4, KATP1, KIR3.4, LQT13, potassium voltage-gated channel subfamily J member 5, potassium inwardly rectifying channel subfamily J member 5
External IDs	OMIM: 600734; MGI: 104755; HomoloGene: 20248; GeneCards: KCNJ5; OMA:KCNJ5 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	128,921,163 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	32,255,646 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; endothelial cell; ; adrenal cortex; ; right adrenal gland; ; left adrenal gland; ; left adrenal cortex; ; right adrenal cortex; ; tendon of biceps brachii; ; right ventricle; ; myocardium;
	Top expressed in
	atrium; ; atrioventricular valve; ; aortic valve; ; olfactory epithelium; ; endocardial cushion; ; right lobe of liver; ; myocardium of ventricle; ; supraoptic nucleus; ; right ventricle; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	G-protein activated inward rectifier potassium channel activity; protein binding; inward rectifier potassium channel activity; voltage-gated ion channel activity; voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization;
Cellular component	integral component of membrane; T-tubule; plasma membrane; membrane; external side of plasma membrane; voltage-gated potassium channel complex;
Biological process	potassium ion transport; regulation of ion transmembrane transport; ion transport; regulation of heart rate by cardiac conduction; membrane repolarization during atrial cardiac muscle cell action potential; membrane repolarization during ventricular cardiac muscle cell action potential; ventricular cardiac muscle cell membrane repolarization; potassium ion import across plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	3762
	16521
	ENSG00000120457
	ENSMUSG00000032034
	P48544
	P48545
	NM_000890; NM_001354169
	NM_010605
	NP_000881; NP_001341098
	NP_034735
	Wikidata
View/Edit Human	View/Edit Mouse

G protein-activated inward rectifier potassium channel 4 (GIRK-4) is a protein that in humans is encoded by the KCNJ5 gene and is a type of G protein-gated ion channel.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000120457 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032034 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA (December 2005). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacological Reviews. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105. S2CID 11588492.
^ "Entrez Gene: KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000120457 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032034 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16382105-5] Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA (December 2005). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacological Reviews. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105. S2CID 11588492.

[entrez-6] "Entrez Gene: KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5".

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