KCNK18

KCNK18
Identifiers
Aliases	KCNK18, K2p18.1, MGR13, TRESK, TRESK-2, TRESK2, TRIK, potassium two pore domain channel subfamily K member 18
External IDs	OMIM: 613655; MGI: 2685627; HomoloGene: 133808; GeneCards: KCNK18; OMA:KCNK18 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	117,210,299 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	59,225,806 bp
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; caudate nucleus; ; prefrontal cortex; ; hypothalamus; ; renal cortex; ; anterior cingulate cortex;
	Top expressed in
	zygote; ; secondary oocyte; ; primary oocyte; ; embryo; ; placenta;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium-activated potassium channel activity; outward rectifier potassium channel activity; potassium channel activity; potassium ion leak channel activity;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane;
Biological process	potassium ion transport; cellular response to pH; ion transport; potassium ion transmembrane transport; stabilization of membrane potential; potassium ion export across plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	338567
	332396
	ENSG00000186795
	ENSMUSG00000040901
	Q7Z418
	Q6VV64
	NM_181840
	NM_207261
	NP_862823
	NP_997144
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium channel subfamily K member 18 (KCNK18), also known as TWIK-related spinal cord potassium channel (TRESK) or K_2P18.1 is a protein that in humans is encoded by the KCNK18 gene. K_2P18.1 is a potassium channel containing two pore-forming P domains.^[5]

A flaw in this gene could help trigger migraine headaches. If the gene does not work properly, environmental factors can more easily trigger pain centres in the brain and cause a severe headache.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186795 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040901 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol. Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.
^
Lafrenière RG, Cader MZ, Poulin JF, Andres-Enguix I, Simoneau M, Gupta N, Boisvert K, Lafrenière F, McLaughlan S, Dubé MP, Marcinkiewicz MM, Ramagopalan S, Ansorge O, Brais B, Sequeiros J, Pereira-Monteiro JM, Griffiths LR, Tucker SJ, Ebers G, Rouleau GA (September 2010). "A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura". Nature Medicine. 16 (10): 1157–1160. doi:10.1038/nm.2216. PMID 20871611. S2CID 205387180.
- "Migraine cause 'identified' as genetic defect". BBC News. 2010-09-27.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000186795 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040901 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16382106-5] Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol. Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.

[Lafrenière_2010-6] Lafrenière RG, Cader MZ, Poulin JF, Andres-Enguix I, Simoneau M, Gupta N, Boisvert K, Lafrenière F, McLaughlan S, Dubé MP, Marcinkiewicz MM, Ramagopalan S, Ansorge O, Brais B, Sequeiros J, Pereira-Monteiro JM, Griffiths LR, Tucker SJ, Ebers G, Rouleau GA (September 2010). "A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura". Nature Medicine. 16 (10): 1157–1160. doi:10.1038/nm.2216. PMID 20871611. S2CID 205387180.
"Migraine cause 'identified' as genetic defect". BBC News. 2010-09-27.

[7] "Migraine cause 'identified' as genetic defect". BBC News. 2010-09-27.

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