KCNK2

KCNK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4TWK
Identifiers
Aliases	KCNK2, K2p2.1, TPKC1, TREK, TREK-1, TREK1, hTREK-1c, hTREK-1e, potassium two pore domain channel subfamily K member 2
External IDs	OMIM: 603219; MGI: 109366; HomoloGene: 7794; GeneCards: KCNK2; OMA:KCNK2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	215,237,090 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	189,134,470 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; Achilles tendon; ; ganglionic eminence; ; cartilage tissue; ; testicle; ; tibial nerve; ; prefrontal cortex;
	Top expressed in
	median eminence; ; arcuate nucleus; ; olfactory tubercle; ; ventromedial nucleus; ; nucleus accumbens; ; piriform cortex; ; gastrula; ; paraventricular nucleus of hypothalamus; ; vestibular membrane of cochlear duct; ; calvaria;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	potassium channel activity; voltage-gated potassium channel activity; potassium channel inhibitor activity; outward rectifier potassium channel activity; potassium ion leak channel activity;
Cellular component	axon terminus; integral component of membrane; endoplasmic reticulum membrane; membrane; voltage-gated potassium channel complex; plasma membrane; astrocyte projection; calyx of Held; cell surface; axon; soma; apical plasma membrane; endoplasmic reticulum; neuron projection; nucleus; integral component of plasma membrane;
Biological process	cochlea development; G protein-coupled receptor signaling pathway; positive regulation of cell death; positive regulation of cellular response to hypoxia; regulation of membrane potential; cardiac ventricle development; response to mechanical stimulus; memory; ion transport; potassium ion transport; response to axon injury; potassium ion transmembrane transport; negative regulation of cardiac muscle cell proliferation; cellular response to hypoxia; negative regulation of DNA biosynthetic process; stabilization of membrane potential;
	Sources:Amigo / QuickGO
Orthologs
	3776
	16526
	ENSG00000082482
	ENSMUSG00000037624
	O95069
	P97438
	NM_001017424; NM_001017425; NM_014217
	NM_001159850; NM_001281847; NM_001281848; NM_010607; NM_001357119
	NP_001017424; NP_001017425; NP_055032
NP_001153322; NP_001268776; NP_001268777; NP_034737; NP_001344048;
	NP_001389703; NP_001389704; NP_001389705; NP_001389755; NP_001389756
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium channel subfamily K member 2, also known as TREK-1, is a protein that in humans is encoded by the KCNK2 gene.^[5]^[6]^[7]

This gene encodes K_2P2.1, a lipid-gated ion channel belonging to the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that releases potassium out of the cell to control resting membrane potential. The channel is opened by anionic lipid, certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000082482 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037624 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lesage F, Lazdunski M (Oct 1998). "Mapping of human potassium channel genes TREK-1 (KCNK2) and TASK (KCNK3) to chromosomes 1q41 and 2p23". Genomics. 51 (3): 478–9. doi:10.1006/geno.1998.5397. PMID 9721223.
^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.
^ ^a ^b "Entrez Gene: KCNK2 potassium channel, subfamily K, member 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000082482 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037624 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9721223-5] Lesage F, Lazdunski M (Oct 1998). "Mapping of human potassium channel genes TREK-1 (KCNK2) and TASK (KCNK3) to chromosomes 1q41 and 2p23". Genomics. 51 (3): 478–9. doi:10.1006/geno.1998.5397. PMID 9721223.

[pmid16382106-6] Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.

[entrez-7] "Entrez Gene: KCNK2 potassium channel, subfamily K, member 2".

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