KCNK4

KCNK4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3UM7, 4I9W, 4RUE, 4RUF, 4WFE, 4WFF, 4WFG, 4WFH
Identifiers
Aliases	KCNK4, K2p4.1, TRAAK, TRAAK1, potassium two pore domain channel subfamily K member 4, FHEIG
External IDs	OMIM: 605720; MGI: 1298234; HomoloGene: 7391; GeneCards: KCNK4; OMA:KCNK4 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	64,300,031 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	6,911,883 bp
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; temporal lobe; ; amygdala; ; hippocampus proper; ; superior frontal gyrus; ; prefrontal cortex; ; anterior cingulate cortex; ; right frontal lobe; ; dorsolateral prefrontal cortex; ; caudate nucleus;
	Top expressed in
	primary visual cortex; ; morula; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; lip; ; entorhinal cortex; ; intestinal villus; ; esophagus; ; Ileal epithelium; ; CA3 field;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	potassium channel activity; mechanosensitived potassium channel activity; voltage-gated ion channel activity; temperature-gated cation channel activity; potassium ion leak channel activity; identical protein binding;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; potassium channel complex;
Biological process	sensory perception of temperature stimulus; regulation of ion transmembrane transport; cellular response to alkaline pH; memory; ion transport; cellular response to temperature stimulus; potassium ion transport; cellular response to mechanical stimulus; cellular response to fatty acid; potassium ion transmembrane transport; sensory perception of pain; detection of mechanical stimulus involved in sensory perception of touch; stabilization of membrane potential;
	Sources:Amigo / QuickGO
Orthologs
	50801
	16528
	ENSG00000182450
	ENSMUSG00000024957
	Q9NYG8
	O88454
	NM_016611; NM_033310; NM_001317090
	NM_008431
	NP_001304019; NP_201567
	NP_032457
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium channel subfamily K member 4 is a protein that in humans is encoded by the KCNK4 gene.^[5]^[6]^[7] KCNK4 protein channels are also called TRAAK channels.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182450 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024957 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lesage F, Maingret F, Lazdunski M (April 2000). "Cloning and expression of human TRAAK, a polyunsaturated fatty acids-activated and mechano-sensitive K(+) channel". FEBS Letters. 471 (2–3): 137–140. Bibcode:2000FEBSL.471..137L. doi:10.1016/S0014-5793(00)01388-0. PMID 10767409. S2CID 31793244.
^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacological Reviews. 57 (4): 527–540. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.
^ "Entrez Gene: KCNK4 potassium channel, subfamily K, member 4".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000182450 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024957 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10767409-5] Lesage F, Maingret F, Lazdunski M (April 2000). "Cloning and expression of human TRAAK, a polyunsaturated fatty acids-activated and mechano-sensitive K(+) channel". FEBS Letters. 471 (2–3): 137–140. Bibcode:2000FEBSL.471..137L. doi:10.1016/S0014-5793(00)01388-0. PMID 10767409. S2CID 31793244.

[pmid16382106-6] Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacological Reviews. 57 (4): 527–540. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.

[entrez-7] "Entrez Gene: KCNK4 potassium channel, subfamily K, member 4".

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