KCNK5

KCNK5
Identifiers
AliasesKCNK5, K2p5.1, TASK-2, TASK2, KCNK5b, potassium two pore domain channel subfamily K member 5
External IDsOMIM: 603493; MGI: 1336175; HomoloGene: 2773; GeneCards: KCNK5; OMA:KCNK5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003740

NM_021542

RefSeq (protein)

NP_003731

NP_067517

Location (UCSC)Chr 6: 39.19 – 39.23 MbChr 14: 20.19 – 20.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Potassium channel subfamily K member 5 is a protein that in humans is encoded by the KCNK5 gene.[5][6][7]

This gene encodes K2P5.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport.[7]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164626Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023243Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Reyes R, Duprat F, Lesage F, Fink M, Salinas M, Farman N, Lazdunski M (Dec 1998). "Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney". J Biol Chem. 273 (47): 30863–9. doi:10.1074/jbc.273.47.30863. PMID 9812978.
  6. ^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.
  7. ^ a b "Entrez Gene: KCNK5 potassium channel, subfamily K, member 5".