KCNMB3

KCNMB3
Identifiers
Aliases	KCNMB3, BKBETA3, HBETA3, K(VCA)BETA-3, KCNMB2, KCNMBL, SLO-BETA-3, SLOBETA3, potassium calcium-activated channel subfamily M regulatory beta subunit 3
External IDs	OMIM: 605222; MGI: 3612244; HomoloGene: 18141; GeneCards: KCNMB3; OMA:KCNMB3 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	179,267,002 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	32,546,380 bp
RNA expression pattern
	Top expressed in
	primary visual cortex; ; testicle; ; gonad; ; body of pancreas; ; spleen; ; placenta; ; sural nerve; ; apex of heart; ; subcutaneous adipose tissue; ; right lobe of liver;
	Top expressed in
	zygote; ; secondary oocyte; ; primary oocyte; ; embryo; ; adrenal gland; ; hypothalamus; ; blastocyst; ; proximal tubule; ; striatum of neuraxis; ; spermatocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium-activated potassium channel activity; potassium channel regulator activity;
Cellular component	integral component of membrane; voltage-gated potassium channel complex; plasma membrane; integral component of plasma membrane; membrane;
Biological process	detection of calcium ion; action potential; ion transport; neuronal action potential; potassium ion transport; potassium ion transmembrane transport; chemical synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	27094
	100502876
	ENSG00000171121
	ENSMUSG00000091091
	Q9NPA1
	E9Q7U0
	NM_001163677; NM_014407; NM_171828; NM_171829; NM_171830
	NM_001195074
	NP_001157149; NP_055222; NP_741979; NP_741980; NP_741981
	NP_001182003
	Wikidata
View/Edit Human	View/Edit Mouse

Calcium-activated potassium channel subunit beta-3 is a protein that in humans is encoded by the KCNMB3 gene.^[5]^[6]

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. At least four transcript variants encoding four different isoforms have been found for this gene.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171121 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000091091 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Riazi MA, Brinkman-Mills P, Johnson A, Naylor SL, Minoshima S, Shimizu N, Baldini A, McDermid HE (Feb 2000). "Identification of a putative regulatory subunit of a calcium-activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2". Genomics. 62 (1): 90–4. doi:10.1006/geno.1999.5975. PMID 10585773.
^ ^a ^b "Entrez Gene: KCNMB3 potassium large conductance calcium-activated channel, subfamily M beta member 3".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171121 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000091091 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10585773-5] Riazi MA, Brinkman-Mills P, Johnson A, Naylor SL, Minoshima S, Shimizu N, Baldini A, McDermid HE (Feb 2000). "Identification of a putative regulatory subunit of a calcium-activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2". Genomics. 62 (1): 90–4. doi:10.1006/geno.1999.5975. PMID 10585773.

[entrez-6] "Entrez Gene: KCNMB3 potassium large conductance calcium-activated channel, subfamily M beta member 3".

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