KCNS1

KCNS1
Identifiers
Aliases	KCNS1, KV9.1, potassium voltage-gated channel modifier subfamily S member 1
External IDs	OMIM: 602905; MGI: 1197019; HomoloGene: 20517; GeneCards: KCNS1; OMA:KCNS1 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	45,101,127 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	164,013,033 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; primary visual cortex; ; cardia; ; Brodmann area 46; ; superior frontal gyrus; ; postcentral gyrus; ; orbitofrontal cortex; ; spinal ganglia; ; ventral tegmental area;
	Top expressed in
	lumbar spinal ganglion; ; parotid gland; ; superior frontal gyrus; ; primary visual cortex; ; calvaria; ; embryo; ; embryo; ; dentate gyrus of hippocampal formation granule cell; ; entorhinal cortex; ; primary motor cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	voltage-gated potassium channel activity; ion channel activity; potassium channel regulator activity; potassium channel activity; protein binding; delayed rectifier potassium channel activity; voltage-gated ion channel activity;
Cellular component	integral component of membrane; membrane; voltage-gated potassium channel complex; plasma membrane; perinuclear region of cytoplasm;
Biological process	regulation of ion transmembrane transport; protein homooligomerization; ion transport; transmembrane transport; potassium ion transmembrane transport; regulation of delayed rectifier potassium channel activity; potassium ion transport;
	Sources:Amigo / QuickGO
Orthologs
	3787
	16538
	ENSG00000124134
	ENSMUSG00000040164
	Q96KK3
	O35173
	NM_002251; NM_001322799
	NM_008435
	NP_001309728; NP_002242
	NP_032461
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium voltage-gated channel subfamily S member 1 is a protein that in humans is encoded by the KCNS1 gene.^[5]^[6] The protein encoded by this gene is a voltage-gated potassium channel subunit.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124134 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040164 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Salinas M, Duprat F, Heurteaux C, Hugnot JP, Lazdunski M (Oct 1997). "New modulatory alpha subunits for mammalian Shab K+ channels". J Biol Chem. 272 (39): 24371–9. doi:10.1074/jbc.272.39.24371. PMID 9305895.
^ ^a ^b Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124134 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040164 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9305895-5] Salinas M, Duprat F, Heurteaux C, Hugnot JP, Lazdunski M (Oct 1997). "New modulatory alpha subunits for mammalian Shab K+ channels". J Biol Chem. 272 (39): 24371–9. doi:10.1074/jbc.272.39.24371. PMID 9305895.

[pmid16382104-6] Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

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