KEAP1

KEAP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1U6D, 1ZGK, 2FLU, 3VNG, 3VNH, 3ZGC, 3ZGD, 4CXI, 4CXJ, 4CXT, 4IFJ, 4IFL, 4IFN, 4IN4, 4IQK, 4L7B, 4L7C, 4L7D, 4N1B, 4XMB
Identifiers
Aliases	KEAP1, INrf2, KLHL19, kelch like ECH associated protein 1
External IDs	OMIM: 606016; MGI: 1858732; HomoloGene: 8184; GeneCards: KEAP1; OMA:KEAP1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	10,503,558 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	21,150,657 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; gastrocnemius muscle; ; apex of heart; ; Skeletal muscle tissue of rectus abdominis; ; stromal cell of endometrium; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; C1 segment; ; glutes; ; Skeletal muscle tissue of biceps brachii;
	Top expressed in
	supraoptic nucleus; ; ascending aorta; ; muscle of thigh; ; aortic valve; ; trigeminal ganglion; ; Paneth cell; ; arcuate nucleus; ; renal corpuscle; ; dorsal tegmental nucleus; ; skeletal muscle tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transcription factor binding; ubiquitin-protein transferase activity; protein binding; protein homodimerization activity; disordered domain specific binding; identical protein binding;
Cellular component	cytoplasm; Cul3-RING ubiquitin ligase complex; nucleoplasm; microtubule organizing center; midbody; endoplasmic reticulum; actin filament; nucleus; cytosol; protein-containing complex;
Biological process	cellular response to interleukin-4; regulation of epidermal cell differentiation; regulation of transcription, DNA-templated; in utero embryonic development; proteasomal ubiquitin-independent protein catabolic process; negative regulation of DNA-binding transcription factor activity; transcription, DNA-templated; protein ubiquitination; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; cytoplasmic sequestering of transcription factor; protein deubiquitination; post-translational protein modification; viral process;
	Sources:Amigo / QuickGO
Orthologs
	9817
	50868
	ENSG00000079999
	ENSMUSG00000003308
	Q14145
	Q9Z2X8
	NM_012289; NM_203500
	NM_001110305; NM_001110306; NM_001110307; NM_016679
	NP_036421; NP_987096
	NP_001103775; NP_001103776; NP_001103777; NP_057888
	Wikidata
View/Edit Human	View/Edit Mouse

Kelch-like ECH-associated protein 1 is a protein that in humans is encoded by the Keap1 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000079999 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003308 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: KEAP1 kelch-like ECH-associated protein 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000079999 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003308 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: KEAP1 kelch-like ECH-associated protein 1".

[1]

[2]

[3]

[4]

[5]