KHDRBS1

KHDRBS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XA6, 3QHE
Identifiers
Aliases	KHDRBS1, Sam68, p62, p68, KH domain containing, RNA binding, signal transduction associated 1, KH RNA binding domain containing, signal transduction associated 1
External IDs	OMIM: 602489; MGI: 893579; HomoloGene: 4781; GeneCards: KHDRBS1; OMA:KHDRBS1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p35.2 Start 32,013,868 bp[1] End 32,060,850 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.2 Start 129,596,957 bp[2] End 129,636,096 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium ganglionic eminence parietal pleura tendon of biceps brachii visceral pleura ventricular zone superficial temporal artery mucosa of paranasal sinus gingival epithelium lower lobe of lung Top expressed in mandibular prominence maxillary prominence ganglionic eminence medial ganglionic eminence somite primitive streak abdominal wall ventricular zone human fetus atrium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding poly(A) binding poly(U) RNA binding SH3 domain binding protein-containing complex binding protein binding RNA binding nucleic acid binding protein domain specific binding identical protein binding Cellular component cytoplasm Grb2-Sos complex membrane nucleus cytosol nucleoplasm Biological process regulation of transcription, DNA-templated regulation of protein stability transcription, DNA-templated positive regulation of RNA export from nucleus cell surface receptor signaling pathway G2/M transition of mitotic cell cycle regulation of RNA export from nucleus cell cycle cell population proliferation negative regulation of transcription, DNA-templated positive regulation of translational initiation signal transduction mRNA processing positive regulation of signal transduction regulation of mRNA splicing, via spliceosome spermatogenesis protein complex oligomerization regulation of alternative mRNA splicing, via spliceosome G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10657 20218 Ensembl ENSG00000121774 ENSMUSG00000028790 UniProt Q07666 Q60749 RefSeq (mRNA) NM_001271878 NM_006559 NM_011317 RefSeq (protein) NP_001258807 NP_006550 NP_035447 Location (UCSC) Chr 1: 32.01 – 32.06 Mb Chr 4: 129.6 – 129.64 Mb PubMed search [3] [4]
Wikidata
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KH domain-containing, RNA-binding, signal transduction-associated protein 1 is a protein that in humans is encoded by the KHDRBS1 gene.^[5][6]

This gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-associated protein family. The encoded protein appears to have many functions and may be involved in a variety of cellular processes, including alternative splicing, cell cycle regulation, RNA 3'-end formation, tumorigenesis, and regulation of human immunodeficiency virus gene expression.^[7]