KIF1A

KIF1A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4EGX, 4EJQ, 4UXO, 4UXP, 4UXR, 4UXS
Identifiers
Aliases	KIF1A, ATSV, C2orf20, HSN2C, MRD9, SPG30, UNC104, kinesin family member 1A
External IDs	OMIM: 601255; MGI: 108391; HomoloGene: 99729; GeneCards: KIF1A; OMA:KIF1A - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	240,821,036 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	93,029,673 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; postcentral gyrus; ; lateral nuclear group of thalamus; ; cerebellar vermis; ; pons; ; anterior cingulate cortex; ; Pars compacta; ; right hemisphere of cerebellum; ; amygdala; ; dorsolateral prefrontal cortex;
	Top expressed in
	superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; neural layer of retina; ; cerebellar cortex; ; medial dorsal nucleus; ; primary visual cortex; ; habenula; ; dorsomedial hypothalamic nucleus; ; medial geniculate nucleus; ; pontine nuclei;
	More reference expression data
	n/a
Gene ontology
Molecular function	microtubule binding; microtubule motor activity; nucleotide binding; ATPase activity; cytoskeletal motor activity; ATP binding; identical protein binding; protein homodimerization activity; plus-end-directed microtubule motor activity;
Cellular component	cytoplasm; microtubule; cytoskeleton; kinesin complex; axon cytoplasm; axon; cytosol; synaptic vesicle; dendrite; neuronal cell body; presynapse; postsynapse; protein-containing complex; neuron projection;
Biological process	microtubule-based movement; anterograde axonal transport; interkinetic nuclear migration; protein transport along microtubule; vesicle-mediated transport; cytoskeleton-dependent intracellular transport; anterograde neuronal dense core vesicle transport; retrograde neuronal dense core vesicle transport;
	Sources:Amigo / QuickGO
Orthologs
	547
	16560
	ENSG00000130294
	ENSMUSG00000014602
	Q12756
	P33173
	NM_001244008; NM_004321; NM_001320705; NM_001330289; NM_001330290
	NM_001110315; NM_001294149; NM_001294150; NM_008440; NM_001368847
	NP_001230937; NP_001307634; NP_001317218; NP_001317219; NP_004312
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Kinesin-like protein KIF1A, also known as axonal transporter of synaptic vesicles or microtubule-based motor KIF1A, is a protein that in humans is encoded by the KIF1A gene.^[5]^[6]^[7]

KIF1A is a neuron-specific member of the kinesin-3 family and is a microtubule plus end-directed motor protein involved in the anterograde, long-distance transport of vesicles and organelles. Similar to other kinesin proteins, KIF1A harnesses the chemical energy released from Adenosine Triphosphate (ATP) hydrolysis to create mechanical force, allowing it to “walk” along microtubule filaments to transport cargo from the neuron cell body to its periphery. With an important role in the brain, KIF1A function is essential for physiological processes, such as neuronal survival and higher brain function.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130294 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000014602 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: kinesin family member 1A".
^ Okada Y, Yamazaki H, Sekine-Aizawa Y, Hirokawa N (June 1995). "The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors". Cell. 81 (5): 769–80. doi:10.1016/0092-8674(95)90538-3. PMID 7539720. S2CID 16772001.
^ Keller MP, Seifried BA, Rabin BA, Chance PF (March 1999). "Mapping of the kinesin-related gene ATSV to chromosome 2q37". Hum. Genet. 104 (3): 254–6. doi:10.1007/s004390050944. PMID 10323250. S2CID 10375316.
^ Siddiqui N, Straube A (July 2017). "Intracellular Cargo Transport by Kinesin-3 Motors" (PDF). Biochemistry. Biokhimiia. 82 (7): 803–815. doi:10.1134/S0006297917070057. PMC 7612238. PMID 28918744. S2CID 20811770.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130294 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000014602 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: kinesin family member 1A".

[pmid7539720-6] Okada Y, Yamazaki H, Sekine-Aizawa Y, Hirokawa N (June 1995). "The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors". Cell. 81 (5): 769–80. doi:10.1016/0092-8674(95)90538-3. PMID 7539720. S2CID 16772001.

[pmid10323250-7] Keller MP, Seifried BA, Rabin BA, Chance PF (March 1999). "Mapping of the kinesin-related gene ATSV to chromosome 2q37". Hum. Genet. 104 (3): 254–6. doi:10.1007/s004390050944. PMID 10323250. S2CID 10375316.

[8] Siddiqui N, Straube A (July 2017). "Intracellular Cargo Transport by Kinesin-3 Motors" (PDF). Biochemistry. Biokhimiia. 82 (7): 803–815. doi:10.1134/S0006297917070057. PMC 7612238. PMID 28918744. S2CID 20811770.

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