KIF5B

KIF5B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BG2, 1MKJ, 2P4N, 3J8X, 3J8Y, 4HNA, 4LNU
Identifiers
Aliases	KIF5B, HEL-S-61, KINH, KNS, KNS1, UKHC, kinesin family member 5B
External IDs	OMIM: 602809; MGI: 1098268; HomoloGene: 55829; GeneCards: KIF5B; OMA:KIF5B - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	32,056,425 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	6,242,174 bp
RNA expression pattern
	Top expressed in
	tail of epididymis; ; caput epididymis; ; optic nerve; ; corpus epididymis; ; mucosa of paranasal sinus; ; inferior ganglion of vagus nerve; ; visceral pleura; ; lower lobe of lung; ; internal globus pallidus; ; Skeletal muscle tissue of biceps brachii;
	Top expressed in
	globus pallidus; ; lateral geniculate nucleus; ; atrioventricular valve; ; ventral tegmental area; ; pontine nuclei; ; epithelium of lens; ; lateral hypothalamus; ; deep cerebellar nuclei; ; seminal vesicula; ; epithelium of stomach;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	microtubule motor activity; nucleotide binding; microtubule binding; protein binding; plus-end-directed microtubule motor activity; ATP binding; JUN kinase binding; cadherin binding; microtubule lateral binding; identical protein binding; ATPase activity;
Cellular component	vesicle; membrane; kinesin complex; endocytic vesicle; microtubule organizing center; membrane-bounded organelle; ciliary rootlet; perinuclear region of cytoplasm; neuron projection; microtubule; cytoskeleton; axonal growth cone; cytoplasm; cytosol; microtubule cytoskeleton; phagocytic vesicle; axon cytoplasm;
Biological process	cytoskeleton-dependent intracellular transport; plus-end-directed vesicle transport along microtubule; cytoplasm organization; vesicle transport along microtubule; positive regulation of potassium ion transport; regulation of membrane potential; positive regulation of synaptic transmission, GABAergic; axon guidance; microtubule-based movement; stress granule disassembly; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of intracellular protein transport; positive regulation of voltage-gated sodium channel activity; positive regulation of vesicle fusion; centrosome localization; brain development; hippocampus development; positive regulation of protein localization to plasma membrane; cellular response to interferon-gamma; anterograde axonal protein transport; anterograde neuronal dense core vesicle transport; retrograde neuronal dense core vesicle transport;
	Sources:Amigo / QuickGO
Orthologs
	3799
	16573
	ENSG00000170759
	ENSMUSG00000006740
	P33176
	Q61768
	NM_004521
	NM_008448
	NP_004512
	NP_032474
	Wikidata
View/Edit Human	View/Edit Mouse

Kinesin family member 5B (KIF5B) is a protein that in humans is encoded by the KIF5B gene.^[5]^[6] It is part of the kinesin family of motor proteins.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170759 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006740 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Navone F, Niclas J, Hom-Booher N, Sparks L, Bernstein HD, McCaffrey G, Vale RD (Jun 1992). "Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells". The Journal of Cell Biology. 117 (6): 1263–75. doi:10.1083/jcb.117.6.1263. PMC 2289507. PMID 1607388.
^ "Entrez Gene: KIF5B kinesin family member 5B".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170759 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006740 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1607388-5] Navone F, Niclas J, Hom-Booher N, Sparks L, Bernstein HD, McCaffrey G, Vale RD (Jun 1992). "Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells". The Journal of Cell Biology. 117 (6): 1263–75. doi:10.1083/jcb.117.6.1263. PMC 2289507. PMID 1607388.

[entrez-6] "Entrez Gene: KIF5B kinesin family member 5B".

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