Kaliotoxin

The amino acid sequence of Kaliotoxin
N - Gly - Val - Glu - Ile - Asn - Val - Lys - Cys - Ser - Gly - Ser - Pro - Gln - Cys - Leu - Lys - Pro - Cys - Lys - Asp - Ala - Gly - Met - Arg - Phe - Gly - Lys - Cys - Met - Asn - Arg - Lys - Cys - His - Cys - Thr - Pro - Lys - OH

Kaliotoxin (KTX) inhibits potassium flux through the Kv1.3 voltage-gated potassium channel and calcium-activated potassium channels by physically blocking the channel-entrance and inducing a conformational change in the K+-selectivity filter of the channel.[1]

  1. ^ Yu, Kunqian; Fu, Wei; Liu, Hong; Luo, Xiaomin; Chen, Kai Xian; Ding, Jianping; Shen, Jianhua; Jiang, Hualiang (2004). "Computational Simulations of Interactions of Scorpion Toxins with the Voltage-Gated Potassium Ion Channel". Biophysical Journal. 86 (6): 3542–3555. Bibcode:2004BpJ....86.3542Y. doi:10.1529/biophysj.103.039461. PMC 1304258. PMID 15189853.