Kaolin clotting time

Not to be confused with Kaolin cephalin clotting time.
Kaolin clotting time
Test ofBlood plasma[1]

Kaolin clotting time (KCT) is a sensitive test to detect lupus anticoagulants.[2] There is evidence that suggests it is the most sensitive test for detecting lupus anticoagulants.[3] It can also detect factor VIII inhibitors but is sensitive to unfractionated heparin as well.[4]

The KCT on whole blood is known as the "Activated Clotting Time" (ACT) and is widely used in various instruments during surgery such as cardiac bypass to monitor heparin.[5]

  1. ^ Gronowski, Ann M. (2004). Handbook of Clinical Laboratory Testing During Pregnancy. Springer Science & Business Media. p. 308. ISBN 9781592597871.
  2. ^ Radhakrishnan, Kottayam (2013). "Kaolin Clotting Time". Haemostasis. Methods in Molecular Biology. Vol. 992. pp. 335–339. doi:10.1007/978-1-62703-339-8_25. ISBN 978-1-62703-338-1. PMID 23546725.
  3. ^ Exner, T; Triplett, D. A.; Taberner, D. A.; Howard, M. A.; Harris, E. N. (1990). "Comparison of test methods for the lupus anticoagulant: International survey on lupus anticoagulants-I (ISLA-1)". Thrombosis and Haemostasis. 64 (3): 478–84. doi:10.1055/s-0038-1647340. PMID 2128977. S2CID 32243774.
  4. ^ "Kaolin Clotting Time [KCT]". Archived from the original on 26 November 2014. Retrieved 26 November 2014.
  5. ^ De Vries, A.J.; Lansink-Hartgring, A,O.; Fernhout, F.J.; Huet,R,C,G.; van den Heuvel, E,R. (2017) "The activated clotting time in cardiac surgery: should celite or kaolin be used?" Interact Cardiovascular and Thoracic Surgery. 24 (4): 549-554