Keratin 13

KRT13
Identifiers
Aliases	KRT13, CK13, K13, WSN2, keratin 13
External IDs	OMIM: 148065; MGI: 101925; HomoloGene: 40740; GeneCards: KRT13; OMA:KRT13 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	41,505,705 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	100,012,392 bp
RNA expression pattern
	Top expressed in
	mucosa of pharynx; ; oral cavity; ; gums; ; gingival epithelium; ; body of tongue; ; buccal mucosa cell; ; palpebral conjunctiva; ; vulva; ; superior surface of tongue; ; cervix epithelium;
	Top expressed in
	superior surface of tongue; ; esophagus; ; corneal stroma; ; molar; ; conjunctival fornix; ; umbilical cord; ; lip; ; cervix; ; oral mucosa; ; middle ear;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural molecule activity; protein binding;
Cellular component	intermediate filament cytoskeleton; keratin filament; extracellular exosome; intermediate filament; nucleus; cytosol;
Biological process	cellular response to retinoic acid; response to radiation; cytoskeleton organization; tongue morphogenesis; keratinization; cornification;
	Sources:Amigo / QuickGO
Orthologs
	3860
	16663
	ENSG00000171401
	ENSMUSG00000044041
	P13646
	P08730
	NM_153490; NM_002274
	NM_010662; NM_001313949
	NP_002265; NP_705694
	NP_001300878; NP_034792
	Wikidata
View/Edit Human	View/Edit Mouse

Keratin 13 (or cytokeratin 13) is a protein that in humans is encoded by the KRT13 gene.^[5]^[6]

Keratin 13 is a type I cytokeratin, it is paired with keratin 4 and found in the suprabasal layers of non-cornified stratified epithelia. Mutations in the gene encoding this protein and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171401 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044041 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Romano V, Raimondi E, Bosco P, Feo S, Di Pietro C, Leube RE, Troyanovsky SM, Ceratto N (October 1992). "Chromosomal mapping of human cytokeratin 13 gene (KRT13)". Genomics. 14 (2): 495–7. doi:10.1016/S0888-7543(05)80250-2. PMID 1385306.
^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (July 2006). "New consensus nomenclature for mammalian keratins". J. Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
^ Richard G, De Laurenzi V, Didona B, Bale SJ, Compton JG (December 1995). "Keratin 13 point mutation underlies the hereditary mucosal epithelial disorder white sponge nevus". Nat. Genet. 11 (4): 453–5. doi:10.1038/ng1295-453. PMID 7493031. S2CID 22769768.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171401 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044041 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1385306-5] Romano V, Raimondi E, Bosco P, Feo S, Di Pietro C, Leube RE, Troyanovsky SM, Ceratto N (October 1992). "Chromosomal mapping of human cytokeratin 13 gene (KRT13)". Genomics. 14 (2): 495–7. doi:10.1016/S0888-7543(05)80250-2. PMID 1385306.

[pmid16831889-6] Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (July 2006). "New consensus nomenclature for mammalian keratins". J. Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.

[pmid7493031-7] Richard G, De Laurenzi V, Didona B, Bale SJ, Compton JG (December 1995). "Keratin 13 point mutation underlies the hereditary mucosal epithelial disorder white sponge nevus". Nat. Genet. 11 (4): 453–5. doi:10.1038/ng1295-453. PMID 7493031. S2CID 22769768.

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