Keratin 5

KRT5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3TNU
Identifiers
Aliases	KRT5, CK5, DDD, DDD1, EBS2, K5, KRT5A, keratin 5, EBS2E, EBS2B, EBS2C, EBS1, EBS2A, EBS2F, EBS2D
External IDs	OMIM: 148040; MGI: 96702; HomoloGene: 55461; GeneCards: KRT5; OMA:KRT5 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	52,520,530 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	101,621,333 bp
RNA expression pattern
	Top expressed in
	gums; ; mucosa of pharynx; ; gingival epithelium; ; nipple; ; skin of abdomen; ; skin of arm; ; skin of thigh; ; vulva; ; human penis; ; skin of hip;
	Top expressed in
	lip; ; molar; ; skin of external ear; ; conjunctival fornix; ; skin of abdomen; ; esophagus; ; cornea; ; skin of back; ; mucosa of urinary bladder; ; transitional epithelium of urinary bladder;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	scaffold protein binding; structural constituent of cytoskeleton; protein binding; structural molecule activity;
Cellular component	cytoplasm; cytosol; plasma membrane; keratin filament; extracellular exosome; intermediate filament; membrane; mitochondrion; nucleus;
Biological process	hemidesmosome assembly; epidermis development; cytoskeleton organization; keratinization; cornification;
	Sources:Amigo / QuickGO
Orthologs
	3852
	110308
	ENSG00000186081
	ENSMUSG00000061527
	P13647
	Q922U2
	NM_000424
	NM_027011
	NP_000415
	NP_081287
	Wikidata
View/Edit Human	View/Edit Mouse

Keratin 5, also known as KRT5, K5, or CK5, is a protein that is encoded in humans by the KRT5 gene.^[5]^[6]^[7] It dimerizes with keratin 14 and forms the intermediate filaments (IF) that make up the cytoskeleton of basal epithelial cells.^[8]^[9] This protein is involved in several diseases including epidermolysis bullosa simplex and breast and lung cancers.^[9]^[10]^[11]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186081 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000061527 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: KRT5 keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types)".
^ Lersch R, Fuchs E (Jan 1988). "Sequence and expression of a type II keratin, K5, in human epidermal cells". Molecular and Cellular Biology. 8 (1): 486–93. doi:10.1128/mcb.8.1.486. PMC 363157. PMID 2447486.
^ Eckert RL, Rorke EA (Jun 1988). "The sequence of the human epidermal 58-kD (#5) type II keratin reveals an absence of 5' upstream sequence conservation between coexpressed epidermal keratins". DNA. 7 (5): 337–45. doi:10.1089/dna.1.1988.7.337. PMID 2456903.
^ Chan YM, Yu QC, LeBlanc-Straceski J, Christiano A, Pulkkinen L, Kucherlapati RS, Uitto J, Fuchs E (Apr 1994). "Mutations in the non-helical linker segment L1-2 of keratin 5 in patients with Weber-Cockayne epidermolysis bullosa simplex". Journal of Cell Science. 107 (4): 765–74. doi:10.1242/jcs.107.4.765. PMID 7520042.
^ ^a ^b Atkinson SD, McGilligan VE, Liao H, Szeverenyi I, Smith FJ, Moore CB, McLean WH (Oct 2011). "Development of allele-specific therapeutic siRNA for keratin 5 mutations in epidermolysis bullosa simplex". The Journal of Investigative Dermatology. 131 (10): 2079–86. doi:10.1038/jid.2011.169. PMID 21716320.
^ Mulvihill MS, Kratz JR, Pham P, Jablons DM, He B (Feb 2013). "The role of stem cells in airway repair: implications for the origins of lung cancer". Chinese Journal of Cancer. 32 (2): 71–4. doi:10.5732/cjc.012.10097 (inactive 2024-04-03). PMC 3845611. PMID 23114089.{{cite journal}}: CS1 maint: DOI inactive as of April 2024 (link)
^ van de Rijn M, Perou CM, Tibshirani R, Haas P, Kallioniemi O, Kononen J, Torhorst J, Sauter G, Zuber M, Köchli OR, Mross F, Dieterich H, Seitz R, Ross D, Botstein D, Brown P (Dec 2002). "Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome". The American Journal of Pathology. 161 (6): 1991–1996. doi:10.1016/S0002-9440(10)64476-8. PMC 1850928. PMID 12466114.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000186081 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000061527 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: KRT5 keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types)".

[pmid2447486-6] Lersch R, Fuchs E (Jan 1988). "Sequence and expression of a type II keratin, K5, in human epidermal cells". Molecular and Cellular Biology. 8 (1): 486–93. doi:10.1128/mcb.8.1.486. PMC 363157. PMID 2447486.

[pmid2456903-7] Eckert RL, Rorke EA (Jun 1988). "The sequence of the human epidermal 58-kD (#5) type II keratin reveals an absence of 5' upstream sequence conservation between coexpressed epidermal keratins". DNA. 7 (5): 337–45. doi:10.1089/dna.1.1988.7.337. PMID 2456903.

[Chan-8] Chan YM, Yu QC, LeBlanc-Straceski J, Christiano A, Pulkkinen L, Kucherlapati RS, Uitto J, Fuchs E (Apr 1994). "Mutations in the non-helical linker segment L1-2 of keratin 5 in patients with Weber-Cockayne epidermolysis bullosa simplex". Journal of Cell Science. 107 (4): 765–74. doi:10.1242/jcs.107.4.765. PMID 7520042.

[Atkinson-9] Atkinson SD, McGilligan VE, Liao H, Szeverenyi I, Smith FJ, Moore CB, McLean WH (Oct 2011). "Development of allele-specific therapeutic siRNA for keratin 5 mutations in epidermolysis bullosa simplex". The Journal of Investigative Dermatology. 131 (10): 2079–86. doi:10.1038/jid.2011.169. PMID 21716320.

[Mulvihill-10] Mulvihill MS, Kratz JR, Pham P, Jablons DM, He B (Feb 2013). "The role of stem cells in airway repair: implications for the origins of lung cancer". Chinese Journal of Cancer. 32 (2): 71–4. doi:10.5732/cjc.012.10097 (inactive 2024-04-03). PMC 3845611. PMID 23114089.{{cite journal}}: CS1 maint: DOI inactive as of April 2024 (link)

[Van-11] van de Rijn M, Perou CM, Tibshirani R, Haas P, Kallioniemi O, Kononen J, Torhorst J, Sauter G, Zuber M, Köchli OR, Mross F, Dieterich H, Seitz R, Ross D, Botstein D, Brown P (Dec 2002). "Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome". The American Journal of Pathology. 161 (6): 1991–1996. doi:10.1016/S0002-9440(10)64476-8. PMC 1850928. PMID 12466114.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]