Kinase insert domain receptor

KDR
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKDR, CD309, FLK1, VEGFR, VEGFR2, Kinase insert domain receptor
External IDsOMIM: 191306; MGI: 96683; HomoloGene: 55639; GeneCards: KDR; OMA:KDR - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002253

NM_010612
NM_001363216

RefSeq (protein)

NP_002244

NP_034742
NP_001350145

Location (UCSC)Chr 4: 55.08 – 55.13 MbChr 5: 76.09 – 76.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kinase insert domain receptor (KDR, a type IV receptor tyrosine kinase) also known as vascular endothelial growth factor receptor 2 (VEGFR-2) is a VEGF receptor. KDR is the human gene encoding it. KDR has also been designated as CD309 (cluster of differentiation 309). KDR is also known as Flk1 (Fetal Liver Kinase 1).

The Q472H germline KDR genetic variant affects VEGFR-2 phosphorylation and has been found to associate with microvessel density in NSCLC.[5]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128052Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000062960Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Glubb DM, Cerri E, Giese A, Zhang W, Mirza O, Thompson EE, Chen P, Das S, Jassem J, Rzyman W, Lingen MW, Salgia R, Hirsch FR, Dziadziuszko R, Ballmer-Hofer K, Innocenti F (August 2011). "Novel functional germline variants in the VEGF receptor 2 gene and their effect on gene expression and microvessel density in lung cancer". Clinical Cancer Research. 17 (16): 5257–67. doi:10.1158/1078-0432.CCR-11-0379. PMC 3156871. PMID 21712447.