Kirsch is a German surname. Notable people with the surname include:
- Adam Kirsch (born 1976), an American book critic and writer
- Brandon Kirsch (born 1983), an American football player
- Delbert Kirsch, a Canadian politician
- Don Kirsch (1920–1970), an American college baseball coach
- Ernst Gustav Kirsch (1841–1901), a German engineer
- Helene Kirsch (1906–1999), a German politician
- Irving Kirsch (born 1943), an American professor of psychology
- Johanna Kirsch (1856–1907), a German painter
- Jonathan Kirsch, an American author, lawyer and columnist
- Olga Kirsch (1924–1997), a South African-Israeli poet
- Philippe Kirsch (born 1947), a Canadian lawyer
- Rainer Kirsch (1934–2015), a German writer and poet
- Randell Kirsch, an American singer and songwriter
- Raymond Kirsch (1942–2013), a Luxembourgian businessman
- Robert Kirsch (1922–1980), American literary critic and author
- Roman Kirsch (born 1988), a German entrepreneur
- Russell Kirsch (1929–2020), created America’s first internally programmable computer and first digital image
- Sarah Kirsch (1935–2013), a German poet
- Stan Kirsch (1968–2020), an American actor
- Steve Kirsch (born 1956), an American inventor
- Theodor Franz Wilhelm Kirsch (1818–1889), a German entomologist who specialised in Coleoptera