Ku70

XRCC6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JEQ, 1JEY, 1JJR, 3RZX
Identifiers
Aliases	XRCC6, X-ray repair complementing defective repair in Chinese hamster cells 6, CTC75, CTCBF, G22P1, KU70, ML8, TLAA, X-ray repair cross complementing 6
External IDs	OMIM: 152690; MGI: 95606; HomoloGene: 37483; GeneCards: XRCC6; OMA:XRCC6 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	41,664,048 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	81,924,286 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; ventricular zone; ; islet of Langerhans; ; embryo; ; ganglionic eminence; ; Achilles tendon; ; right adrenal gland; ; thymus; ; beta cell;
	Top expressed in
	thymus; ; otic placode; ; saccule; ; otic vesicle; ; neural layer of retina; ; tail of embryo; ; epiblast; ; ventricular zone; ; genital tubercle; ; right lobe of liver;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; double-stranded telomeric DNA binding; telomeric DNA binding; helicase activity; 5'-deoxyribose-5-phosphate lyase activity; DNA helicase activity; protein C-terminus binding; catalytic activity; protein binding; lyase activity; hydrolase activity; ATP binding; DNA binding; double-stranded DNA binding; damaged DNA binding; RNA binding; cyclin binding; protein-containing complex binding;
Cellular component	cytosol; nuclear telomere cap complex; membrane; transcription regulator complex; chromosome; nucleoplasm; nonhomologous end joining complex; nucleus; Ku70:Ku80 complex; cytoplasm; extracellular region; secretory granule lumen; ficolin-1-rich granule lumen; protein-DNA complex; nucleolus; protein-containing complex;
Biological process	double-strand break repair via classical nonhomologous end joining; protein heterotetramerization; regulation of transcription, DNA-templated; regulation of smooth muscle cell proliferation; transcription, DNA-templated; cellular response to DNA damage stimulus; positive regulation of transcription, DNA-templated; DNA ligation; establishment of integrated proviral latency; metabolism; negative regulation of transcription, DNA-templated; double-strand break repair via nonhomologous end joining; telomere maintenance; positive regulation of type I interferon production; positive regulation of transcription by RNA polymerase II; DNA duplex unwinding; DNA repair; cellular hyperosmotic salinity response; brain development; DNA recombination; neutrophil degranulation; cellular response to gamma radiation; cellular response to X-ray; positive regulation of protein kinase activity; activation of innate immune response; immune system process; innate immune response;
	Sources:Amigo / QuickGO
Orthologs
	2547
	14375
	ENSG00000196419
	ENSMUSG00000022471
	P12956
	P23475
	NM_001469; NM_001288976; NM_001288977; NM_001288978
	NM_010247
NP_001275905; NP_001275906; NP_001275907; NP_001460; NP_001275905.1;
	NP_001460.1
	NP_034377
	Wikidata
View/Edit Human	View/Edit Mouse

Ku70 is a protein that, in humans, is encoded by the XRCC6 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196419 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022471 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cite error: The named reference entrez was invoked but never defined (see the help page).
^ Pace P, Mosedale G, Hodskinson MR, Rosado IV, Sivasubramaniam M, Patel KJ (Jul 2010). "Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway". Science. 329 (5988): 219–23. Bibcode:2010Sci...329..219P. doi:10.1126/science.1192277. PMID 20538911. S2CID 206527645.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196419 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022471 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] Cite error: The named reference entrez was invoked but never defined (see the help page).

[6] Pace P, Mosedale G, Hodskinson MR, Rosado IV, Sivasubramaniam M, Patel KJ (Jul 2010). "Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway". Science. 329 (5988): 219–23. Bibcode:2010Sci...329..219P. doi:10.1126/science.1192277. PMID 20538911. S2CID 206527645.

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