Ku80

XRCC5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JEQ, 1JEY, 1Q2Z, 1RW2, 3RZ9
Identifiers
Aliases	XRCC5, KARP-1, KARP1, KU80, KUB2, Ku86, NFIV, Ku80, X-ray repair complementing defective repair in Chinese hamster cells 5, X-ray repair cross complementing 5
External IDs	OMIM: 194364; MGI: 104517; HomoloGene: 40681; GeneCards: XRCC5; OMA:XRCC5 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q35 Start 216,107,464 bp[1] End 216,206,303 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C3|1 36.5 cM Start 72,346,586 bp[2] End 72,434,111 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in embryo ganglionic eminence ventricular zone islet of Langerhans stromal cell of endometrium bone marrow gonad Achilles tendon bone marrow cells smooth muscle tissue Top expressed in saccule otic placode otic vesicle genital tubercle tail of embryo primary oocyte epiblast right kidney ventricular zone primitive streak More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding nucleotide binding double-stranded telomeric DNA binding telomeric DNA binding helicase activity 5'-deoxyribose-5-phosphate lyase activity DNA helicase activity hydrolase activity, acting on acid anhydrides protein C-terminus binding protein binding hydrolase activity ATP binding ubiquitin protein ligase binding double-stranded DNA binding damaged DNA binding RNA binding enzyme activator activity protein-containing complex binding DNA end binding Cellular component cytoplasm cytosol nuclear telomere cap complex membrane plasma membrane nucleoplasm chromosome nucleolus nonhomologous end joining complex nucleus extracellular region secretory granule lumen protein-DNA complex Ku70:Ku80 complex protein-containing complex site of DNA damage ribonucleoprotein complex Biological process DNA recombination regulation of transcription, DNA-templated regulation of smooth muscle cell proliferation transcription, DNA-templated cellular response to DNA damage stimulus positive regulation of neurogenesis hematopoietic stem cell differentiation double-strand break repair negative regulation of t-circle formation establishment of integrated proviral latency cell population proliferation negative regulation of transcription, DNA-templated positive regulation of type I interferon production cellular hyperosmotic salinity response DNA repair DNA duplex unwinding brain development cellular response to fatty acid double-strand break repair via nonhomologous end joining neutrophil degranulation cellular response to gamma radiation cellular response to X-ray telomere maintenance regulation of telomere maintenance positive regulation of telomere maintenance via telomerase positive regulation of catalytic activity positive regulation of protein kinase activity positive regulation of telomerase activity protein localization to chromosome, telomeric region cellular response to leukemia inhibitory factor activation of innate immune response immune system process innate immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7520 22596 Ensembl ENSG00000079246 ENSMUSG00000026187 UniProt P13010 P27641 RefSeq (mRNA) NM_021141 NM_009533 NM_001357519 NM_001357520 RefSeq (protein) NP_066964 NP_033559 NP_001344448 NP_001344449 Location (UCSC) Chr 2: 216.11 – 216.21 Mb Chr 1: 72.35 – 72.43 Mb PubMed search [3] [4]
Wikidata
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Ku80 is a protein that, in humans, is encoded by the XRCC5 gene.^[5] Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair. It is also required for V(D)J recombination, which utilizes the NHEJ pathway to promote antigen diversity in the mammalian immune system.

In addition to its role in NHEJ, Ku is required for telomere length maintenance and subtelomeric gene silencing.^[6]

Ku was originally identified when patients with systemic lupus erythematosus were found to have high levels of autoantibodies to the protein.^[7]