Kyriakou (Greek: Κυριάκου or Κυριακού), sometimes transliterated as Kiriakou or Kyriacou, is a Greek or – more commonly – a Greek-Cypriot surname. Notable individuals with this surname include:
- Andi Kyriacou, Irish rugby player (born 1983)
- Charalambos Kyriakou (footballer, born 1989), Cypriot association football player (born 1989)
- Charalambos Kyriakou (footballer born 1995), Cypriot association football player (born 1995)
- Demetris Kyriakou, Cypriot association football player (born 1986)
- Emanuel Kiriakou, US-American songwriter and producer
- John Kiriakou, US-American CIA analyst (born 1964)
- Kostas Kyriacou, Cypriot politician (born 1958)
- Kyriacos Kyriacou, Cypriot association football player (born 1989)
- Maria Elena Kiriakou, Cypriot singer, (born 1984)
- Michalis Kyriakou, stage name Mihalis Violaris, Cypriot singer (born 1944)
- Minos Kyriakou, Greek shipping magnate (1942–2017)
- Rena Kyriakou, Greek pianist (1917–1994)
- Xenios Kyriacou, Cypriot association footballer (born 1979)