LAGLIDADG RNA motifs

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LAGLIDADG-2
Consensus secondary structure and sequence conservation of LAGLIDADG-2 RNA
Identifiers
Symbol	LAGLIDADG-2
Rfam	RF03094
Other data
RNA type	Gene; sRNA
SO	SO:0001263
PDB structures	PDBe

LAGLIDADG RNA motifs are conserved RNA structures that were discovered by bioinformatics.^[1] These RNA motifs are associated with genes that encode endonucleases of the LAGLIDADG variety. Although group I introns are often present in self-replicating elements that use LAGLIDADG endonucleases, the known LAGLIDADG RNA motifs appear too small and structurally simple to function as a self-splicing intron.

A LAGLIDADG-1 motif RNA is predicted in the fungus Trametes cingulata as well as many metagenomic sequences, which presumably are derived from other fungi. LAGLIDADG-2 motif RNAs are found in Halobacteria. It is ambiguous whether LAGLIDADG-1 RNAs function as cis-regulatory elements or whether they operate in trans.